The Filled Journal

Retatrutide vs. Ozempic: What Lilly's New Head-to-Head Results Show (and Don't)
Retatrutide vs. Ozempic: What Lilly's New Head-to-Head Results Show (and Don't)
Eli Lilly reported results today from its first Phase 3 head-to-head trial of retatrutide against Ozempic 2 mg in adults with type 2 diabetes. Here are the numbers, the caveats,... Read more...
Peptide Policy Just Reached the White House: What's Pending and What Isn't
Peptide Policy Just Reached the White House: What's Pending and What Isn't
FDA's interim peptide compounding policy is under White House review. Here is what happened, what is still unknown, and why none of it is an approval. Read more...
Prime Editing for Wilson Disease: What the "First Ever" Gene-Editing Headline Really Means
A viral post says the first CRISPR treatment has been injected into humans to rewrite DNA. Here is what the Wilson disease trial actually is, what 'first' means, and what is still unknown. Read more...
GLP-1s and Psychiatric Hospitalization: What the New Lancet Psychiatry Study Actually Found
GLP-1s and Psychiatric Hospitalization: What the New Lancet Psychiatry Study Actually Found
A viral post says GLP-1 use is linked to 25% fewer psychiatric hospitalizations among 70,000 US adults. Here is who was actually studied, what was and wasn't measured, and what... Read more...
A Peptide-Based Therapy For Cancer Just Met Its Phase 3 Goal: What ACTION-1 Means for Peptide Medicine
A Peptide-Based Therapy For Cancer Just Met Its Phase 3 Goal: What ACTION-1 Means for Peptide Medicine
Bristol Myers Squibb reported that RYZ101, a peptide-targeted radiopharmaceutical, met its Phase 3 primary endpoint in neuroendocrine tumors. Here is what the news says, what it doesn't, and what it... Read more...
The "Spiderman" Stack: How BPC-157, TB-500, CJC/Ipamorelin, Semax/Selank, MOTS-c and NAD+ Fit Together and Why Researchers are Calling it The Spiderman Stack
The "Spiderman" Stack: How BPC-157, TB-500, CJC/Ipamorelin, Semax/Selank, MOTS-c and NAD+ Fit Together and Why Researchers are Calling it The Spiderman Stack
Why the five-part peptide stack has people talking: what each component is studied for, how the pieces map to different systems, and what a clinician-guided approach looks like. Read more...
Do You Need to Refrigerate Prescription Peptides?
Do You Need to Refrigerate Prescription Peptides?
Most compounded prescription peptides should be kept cold, but the exact rule is on your pharmacy label. Here is how storage, beyond-use dates, shipping heat and travel work. Read more...
BPC-157 Human Trials: What Is Underway in 2026
BPC-157 Human Trials: What Is Underway in 2026
BPC-157 has decades of animal research and almost no human data. Here is what the first registered human trials are testing, what they cannot answer yet, and when results may... Read more...
Semax and Selank: What the Research Shows
Semax and Selank: What the Research Shows
An evidence-based look at Semax and Selank: what each peptide is, what human and animal research shows, what is still unknown, and where US FDA compounding rules stand in 2026. Read more...
NAD+ Explained: What It Is and Why It Declines With Age
NAD+ Explained: What It Is and Why It Declines With Age
NAD+ shows up in almost every longevity conversation. Here's the actual mechanism — and why supplementing it means taking a precursor, not NAD+ itself. Read more...
CoQ10 vs. Ubiquinol: Does the Form Actually Matter?
CoQ10 supplements come in two chemical forms — ubiquinone and ubiquinol. The difference isn't marketing. Here's what it actually changes. Read more...
What Your Mitochondria Actually Do All Day
Fatigue isn't a mystery — it's a supply chain problem at the cellular level. Here's what mitochondria actually do, and where the process tends to break down. Read more...